UNIT 5 – The Cardiovascular System — The Body’s Lifeline Notes

Health Desk: At the center of human life beats a tireless organ—the heart. Day and night, it pumps blood through a vast network of vessels, sustaining every cell in the body. The cardiovascular system is more than a transport service; it is a lifeline that delivers oxygen, nutrients, and hormones while removing waste. Without it, survival would last only minutes.

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The Heart: An Elegant Pump

The heart is a muscular, cone-shaped organ about the size of a fist. Located in the thoracic cavity, it rests slightly left of center behind the sternum.

Anatomy of the Heart

Internally, the heart is divided into four chambers: two atria (upper chambers) and two ventricles (lower chambers). The right side handles deoxygenated blood, sending it to the lungs, while the left side pumps oxygenated blood to the entire body. Valves—the tricuspid, pulmonary, mitral, and aortic—ensure blood flows in only one direction.

Blood Circulation: Two Loops, One Goal

The cardiovascular system operates in two circuits:

  • Pulmonary circulation: Carries blood from the right ventricle to the lungs for oxygenation and returns it to the left atrium.

  • Systemic circulation: Sends oxygen-rich blood from the left ventricle throughout the body and brings deoxygenated blood back to the right atrium.

Together, these loops form a seamless cycle that repeats about 70–80 times per minute at rest.

Blood Vessels: The Pathways of Life

The vascular network is vast, stretching more than 60,000 miles in an adult body. Each type of vessel plays a specialized role:

Arteries

Arteries carry blood away from the heart under high pressure. Their thick, muscular walls allow them to withstand the force of each heartbeat, with the aorta being the largest artery.

Veins

Veins return blood to the heart. Equipped with valves, they prevent backflow and assist the uphill journey of blood, especially from the legs, back toward the chest.

Capillaries

Capillaries are the microscopic exchange sites where oxygen and nutrients diffuse into tissues and waste products move into blood. Their thin, one-cell-thick walls make them the true connectors of circulation.

The Heart’s Electrical System: Conduction and Beat

Beyond its muscular power, the heart also has its own built-in electrical grid.

Elements of the Conduction System

  • Sinoatrial (SA) node: Known as the natural pacemaker, it initiates each heartbeat.

  • Atrioventricular (AV) node: Delays the signal slightly, allowing the atria to empty before ventricles contract.

  • Bundle of His and Purkinje fibers: Rapidly conduct impulses to ventricular muscles, ensuring a coordinated contraction.

Heartbeat and Its Regulation

The heart contracts rhythmically due to these signals, but its rate is fine-tuned by the autonomic nervous system:

  • The sympathetic system speeds it up during stress or exercise.

  • The parasympathetic system slows it down during rest.

Cardiac Cycle and Output

Each heartbeat consists of a cardiac cycle, lasting about 0.8 seconds at rest. It includes:

  • Atrial systole (atria contract),

  • Ventricular systole (ventricles contract), and

  • Diastole (relaxation phase).

The amount of blood pumped per minute is the cardiac output, calculated as:
Cardiac Output = Stroke Volume × Heart Rate.
On average, this equals about 5 liters per minute—the entire blood volume circulating once every 60 seconds.

Regulation of Blood Pressure and Pulse

Blood pressure is the force exerted by circulating blood on vessel walls. It is regulated by:

  • Neural mechanisms (autonomic nervous system control),

  • Hormonal influences (adrenaline, renin-angiotensin system), and

  • Renal function (kidneys adjusting fluid balance).

The pulse, felt at arteries like the wrist or neck, reflects the rhythmic pressure waves produced by each heartbeat.

Electrocardiogram: Tracing the Heart’s Rhythm

The electrocardiogram (ECG) is a diagnostic tool that records electrical activity of the heart. The classic waves include:

  • P wave: atrial depolarization,

  • QRS complex: ventricular depolarization,

  • T wave: ventricular repolarization.

Doctors rely on ECGs to detect arrhythmias, myocardial infarctions, and conduction abnormalities.

Disorders of the Heart

Despite its resilience, the heart is vulnerable to several conditions:

  • Coronary artery disease (CAD): Blockages in coronary vessels reduce oxygen supply.

  • Heart failure: The heart cannot pump effectively, leading to fluid buildup.

  • Arrhythmias: Irregular heartbeats disrupt normal rhythm.

  • Hypertension: Chronic high blood pressure strains vessels and increases risk of stroke.

Early detection through monitoring pulse, ECGs, and blood pressure remains critical for prevention and treatment.

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